BIFAP is an electronic database made up of medical records from Primary Care destined for pharmacoepidemiological studies and belonging to the Spanish Agency of Medicines and Medical Devices (AEMPS). It features the collaboration of the Autonomous Communities and the support of the main scientific societies involved.
We protect the confidentiality of patient information contained in the database in accordance with current data protection legislation.
We promote the collaboration of Primary Care physicians and maintain high standards of information quality and benefits.
We encourage quality research from Primary Health Care, ensuring high levels of scientific quality.
We develop independent research lines on aspects relevant to the Scientific community and the Public Health of the population.
RESEARCH ON COVID-19 AT BIFAP
Family doctors and paediatricians
Anonymised Electronic Medical Records
Person-years of follow-up
Average years of follow-up per patient
Health problem records
Medication records
Immunisation records
General and analytical data records
If you are a primary care physician from the National Health System in one of the participating autonomous communities you can actively collaborate in the BIFAP programme. As a partner you can also request research studies.
If you are a researcher attached to a public body you can use BIFAP as a source of information to conduct research. Sign up to learn about the process and we'll be in touch with you.
Currently, family doctors or paediatricians who perform a primary care activity of the National Health System in one of the participating Autonomous Communities may be BIFAP collaborators.
It is not an indispensable requirement that they hold a quota, so resident internal doctors, alternate, interim or continued care doctors at Primary Care may also apply to be collaborators.
BIFAP collaborators are Primary Care professionals in participating communities who voluntarily choose to help the BIFAP programme. This help is firstly realized by improving the way they record information during their usual clinical practice. To this end, recommendations on how best to record information are sent to collaborators on a regular basis so that it can be used in epidemiological studies.
Collaborating physicians may, on a voluntary basis, actively participate in improving the quality of BIFAP research by performing some more specific tasks whose dedication time can be quantified to be subsequently recognised:
1. Participating in database quality improvement tasks, dedicating time to perform standardisation tasks related to diagnostic and prescription drug information contained in BIFAP. This standardisation is carried out using online tools made available to collaborating physicians.
2. Providing expert clinical knowledge to help improve the quality of specific studies by other researchers by responding to surveys or conducting their own studies as a principal investigator.
In addition to assisting in the maintenance of a national and public-owned epidemiological source of information aimed at improving the safety of the medicinal product, collaborating physicians are beneficiaries of the following services:
1. They access the BIFAP Services website where they have aggregate statistics on BIFAP patients both globally and within their Autonomous Community. Collaborators who hold a quota also have access to the aggregate data of their patients.
2. They have the specific support of the BIFAP Collaborator Support Unit to carry out their own research studies using BIFAP data.
3. In addition, by filling-in the Profile-Plus, they can share their interests in different areas of research and participate in research studies conducted at BIFAP.
4. All physicians who are registered as BIFAP collaborators and show their commitment to good HCE registration will receive, upon request, a document certifying that as of the day of issue they are listed as BIFAP collaborating physicians.
5. Physicians who have also performed specific database improvement tasks for which the time to perform can be quantified will receive a document certifying the number of hours for each calendar year, provided that they exceed a minimum of 10 hours in that period.
El Comité Asesor tiene funciones consultivas y vela para que BIFAP se consolide y se desarrolle dentro de lo establecido en los convenios de colaboración con las CCAA participantes.
Está compuesto por dos representantes de la Agencia Española de Medicamentos y Productos Sanitarios y un representante de cada una de las Comunidades Autónomas que participan en BIFAP.
1) To promote quality research with the BIFAP database.
2) To evaluate the scientific quality, relevance, feasibility and interest of the study proposals received.
3) To prioritise, if necessary, the implementation of certain projects.
Spokesperson designated by the AEMPS: Lucía Cea Soriano (President)
Spokesperson acting on behalf of the AEMPS: Miguel Ángel Maciá Martínez (Secretary)
Spokespeople acting on behalf of the Advisory Committee: Eduardo Fernández Quintana, Jesús Ruiz Salazar
Spokesperson acting on behalf of public research bodies: Beatriz Pérez Gómez
Spokesperson acting on behalf of the collaborating physicians: Aida Moreno Juste
Spokesperson acting on behalf of the BIFAP team: Elisa Martín Merino
The following are the planned meeting dates of the BIFAP Scientific Committee (Note: they could be changed if necessary):
January 26, 2022
February 23, 2022
March 30, 2022
April 27, 2022
May 25, 2022
June 29, 2022
In order to evaluate the protocols at each meeting, all the necessary documentation must be submitted at least 10 working days before the corresponding meeting. The Scientific Committee will communicate its opinion to the principal investigator normally in less than one month from the request, and within two months at most.
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Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Real-world effectiveness of different COVID-19 vaccines in Spain: a cohort study based on public electronic health records (BIFAP), | Elisa Martín Merino AEMPS | 2021/04/29 | Active |
Rapid Safety Assessment of SARS-CoV-2 vaccines in EU Member States using electronic health care datasources. | Patricia García Poza
AEMPS | 2021/08/30 | Active |
Rapid monitoring of exposure, Adverse Events of Special Interest and COVID-19 diagnoses prior to and after COVID-19 vaccination. | María del Mar Martín Pérez
AEMPS | 2021/02/24 | Active |
Extracción automática de reacciones adversas en textos de Atención Primaria. | Jorge Tenorio Berrio UNED | 2021/05/25 | Active |
Metamizole and risk of agranulocitosis. | Elisa Martín Merino
AEMPS | 2020/12/03 | Active |
Ambulatory use of antibiotics in Spain: an analysis of national prescribing data using the indicators of the National Action Plan on Antimicrobial Resistances. | Carmen Marina Meseguer Barros
Servicio de Farmacia Atención Primaria. Comunidad de Madrid | 2020/12/03 | Active |
Características demográficas, clínicas y de tratamiento de una cohorte de pacientes con covid-19. Datos procedentes de la base de datos BIFAP. | Consuelo Huerta Alvarez
EMA / AEMPS | 2021/01/27 | Active |
Impacto en salud del tratamiento con trinomia en pacientes en prevención primaria y secundaria en vida real. Estudio TRIAP. | Sergio Cinza Sanjurjo
Centro de Salud Porto do Son. Santiago de Compostela | 2021/01/27 | Active |
Comparación de las distintas aproximaciones del índice de propensión y los modelos de regresión para análisis de supervivencia en un escenario real. | Airam de Burgos González AEMPS | 2021/08/30 | Completed |
Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Feasibility analysis of an EU infrastructure for COVID-19 vaccine monitoring. | Consuelo Huerta Alvarez
EMA / AEMPS | 2020/10/28 | Completed |
SYSADOA (symptomatic slow acting drugs for ostearthritis) Y RIESGO CARDIOVASCULAR. | Ramón Mazzucchelli Esteban
Hospital Universitario Fundación Alcorcón Comunidad de Madrid | 2020/07/01 | Completed |
Impact of EU label changes and revised pregnancy prevention programme for oral retinoid containing medicinal products: utilization and prescribing trends. | Consuelo Huerta Alvarez
EMA / AEMPS | 2020/01/23 | Active |
Effect of regulatory interventions on agomelatine incidence rates use in Spain: a multiple intervention time-series analysis in an electronic health care database. | Diana González Bermejo
AEMPS | 2020/03/26 | Active |
Impact of EU label changes and revised pregnancy prevention programme for medicinal products containing valproate: utilisation and prescribing trends. | Consuelo Huerta Alvarez
EMA / AEMPS | 2020/01/23 | Active |
Vacunación antigripal y riesgo de eventos aterotrombóticos (infarto agudo de miocardio y accidentes cerebrovasculares): un estudio de casos y controles de base poblacional. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2020/02/26 | Completed |
Antiplatelet drugs and chemoprevention of digestive cancer: a propensity-score matched cohort study. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2020/03/26 | Active |
COVID-19 y embarazo: Principales efectos en la embarazada y en el desarrollo del embarazo utilizando datos secundarios procedentes de BIFAP. | Lucia Cea Soriano
Universidad Complutense de Madrid | 2020/10/28 | Active |
Deploying of machine learning models for personalized risk stratification and prognosis of renal damage in BIFAP. ML-PRD. | Luis Miguel Ruilope Urioste
Hospital 12 de Octubre Comuniad de Madrid | 2020/09/23 | Active |
Asociación entre el uso de fármacos que bloquean el eje reninaangiotensina-aldosterosa (SRAA) y la incidencia y gravedad de la infección del COVID-19: Un estudio caso-población. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2020/03/26 | Completed |
Estudio de incidencia de Herpes Zóster en pacientes con patología de base: DM, Insuficiencia cardiaca, EPOC y Asma. | Ana Pilar Javierre Miranda
Centro de Salud Montesa Comunidad de Madrid | 2020/01/23 | Active |
Creación de una herramienta para detectar fragilidad en una base de datos poblacional de atención primaria (BIFAP). | María Medina Sampedro
CS Villaviciosa de Odón Villaviciosa de Odón Comunidad de Madrid | 2020/01/23 | Active |
El efecto del subsidio para parados de larga duración en la salud de los trabajadores de mediana edad. | Manuel Serrano Alarcón
Grupo de Investigación de Economía y Salud (CRES) Universitat Pompeu Fabra | 2020/02/26 | Completed |
Efectos a corto plazo del calor y el frío en el uso de medicamentos respiratorios. Un estudio ecológico de series temporales. | Dominic Royé
Universidad Santiago de Compostela | 2020/01/23 | Completed |
Evaluación del riesgo de desarrollar la enfermedad de Alzheimer en personas mayores diagnosticadas de depresión en tratamiento con antidepresivos en monoterapia. | Elena González Burgos
Universidad Complutense de Madrid | 2020/03/26 | Completed |
Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Infección del tracto urinario en adultos en atención primaria en España: incidencia, etiología, prescripción y resistencias antibióticas (2009-2018). ESTUDIO ITURA-AP. | Jesús Redondo Sánchez
CS Ramón y Cajal Alcorcón Comunidad de Madrid | 2019/03/28 | Completed |
Tratamiento del asma: broncodilatadores vs corticoides inhalados. | Miguel Ángel Lobo Álvarez
CEIm-Regional de la Comunidad de Madrid Miembro del Grupo de Respiratorio de la Sociedad Española de Medicina Familiar y Comunitaria | 2019/03/28 | Completed |
Global prescribing trends in antidepressants, opioids and lithium. | María Dolores Montero Corominas
AEMPS | 2019/12/04 | Active |
Changes in alternative treatments for pain and cough in children after introduction of risk minimisation measures for codeine. | Miguel Angel Maciá AEMPS | 2019/09/26 | Completed |
Beneficio clínico neto de los antagonistas de la vitamina K versus anticoagulantes orales de acción directa en fibrilación auricular no valvular. | Juan Erviti López
Servicio Navarro de Salud | 2019/05/08 | Active |
Efecto de la combinación "Triple whammy" en la hospitalización por fallo renal agudo-estudio de casos y controles anidado en una cohorte. | Leire Leache Alegría
Servicio Navarro de Salud-Osasunbidea Sección de Innovación y Organización | 2019/07/04 | Completed |
Análisis de la frecuencia de Hacer lo que No hay que hacer (sobreutilización Inadecuada) en atención primaria en España. Estudio SOBRINA. | María Pilar Astier Peña
CS La Jota Zaragoza Servicio Aragonés de Salud | 2019/03/28 | Completed |
Farmacoepidemiologia del tratamiento psicotrópico en niños y adolescentes. | Diego Pablo Sánchez Martínez
Universidad de Murcia Facultad de Medicina | 2019/10/30 | Completed |
Riesgo De Fracturas Vertebrales Múltiples Tras la Interrupción Del Tratamiento Con Denosumab (Prolia®) en BIFAP. | Maria del Mar Martín Pérez AEMPS | 2019/07/04 | Active |
Estudio de utilización de Fentanilo de liberación inmediata en España. | Diana González Bermejo
AEMPS | 2019/02/26 | Active |
Uso concomitante de tramadol y dabigatran y riesgo de sangrado: Estudio epidemiológico utilizando datos secundarios procedentes de BIFAP. | Lucia Cea Soriano
Universidad Complutense de Madrid | 2019/08/29 | Completed |
Análisis de la exacerbación en el paciente con EPOC según el tipo de tratamiento inhalatorio en Atención Primaria. | Antonio Luis Aguilar Shea.
Centro de salud Puerta de Madrid. Alcalá de Henares. Comunidad de Madrid | 2019/12/04 | Completed |
Contemporary trends in use of antiplatelets, anticoagulants and statins in three european countries. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2019/09/26 | Completed |
Incidencia de arritmias e IC en pacientes tratados con Venlafaxina, Desvenlafaxina y Vortioxetina. Muestra en la vida real. (BIFAP) | José Seijas Amigo
Hospital Clínico Universitario de Santiago | 2019/09/26 | Completed |
Desarrollo y validación de una Escala de Predicción de fracturas Implementable en historia Clínica electrónica: EPIC. | Daniel Martínez Laguna
CAP Sant Martí de Provençals Institut Català de la Salut | 2019/05/08 | Completed |
Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Use of hydrochlorothiazide and risk of skin cancer. | Luz María León Muñoz
AEMPS | 2018/09/27 | Completed |
Use of flecainide and risk of skin cancer. | Luz María León Muñoz
AEMPS | 2018/03/01 | Active |
The prevalence and incidence rate of overweight and obesity among children and adolescents (0 to 17 years) in the BIFAP database. | Talita Duarte Salles
IDIAP Jordi Gol | 2018/06/28 | Completed |
Asociación entre el uso de estatinas y sangrado mayor y accidente cerebrovascular isquémico en pacientes en tratamiento con anticoagulantes de acción directa por fibrilación auricular. | Consuelo Huerta Alvarez
AEMPS/EMA | 2017/11/30 | Active |
Creación y validación de un algoritmo de clasificación de términos médicos en la base de datos BIFAP. | Jesús Santamaría Martínez de la Casa
CNIO (Centro Nacional de Investigaciones Oncológicas) | 2017/11/30 | Completed |
Evolución de la prescripción de neurolépticos en personas con demencia en España. | Francisco Javier Olazarán Rodríguez
Hospital General Universitario Gregorio Marañón Comunidad de Madrid | 2018/03/01 | Completed |
Relación entre la duración del tratamiento con doble antiagregación tras un infarto agudo de miocardio y eventos trombóticos y hemorrágicos en pacientes anticoagulados por fibrilación auricular. | Ana Fernández Vega
Hospital Clínico San Carlos. Comunidad de Madrid | 2018/09/27 | Active |
Prescripción clínica de antibióticos.
| Javier Arranz Izquierdo
CS Arquitecte Bennassar Palma de Mallorca | 2018/05/24 | Completed |
Control de factores riesgo y prevención secundaria en pacientes con muy alto riesgo cardiovascular. | Ana Fernández Vega
Hospital Clínico San Carlos. Comunidad de Madrid | 2018/01/25 | Completed |
Estimación indirecta de la prevalencia de demencia en canarias mediante los datos de consumo de fármacos específicos para la demencia. | Norberto Rodríguez Espinosa
Hospital Universitario Ntra. Señora de Candelaria Tenerife | 2018/07/19 | Completed |
La Depresión en Atención Primaria y su Tratamiento Farmacológico. | Miguel Ángel Mayer Pujadas
Instituto Hospital del Mar de Investigaciones Médicas (IMIM) y Universitat Pompeu Fabra Barcelona | 2018/06/28 | Completed |
El impacto de ayudas públicas a las familias sobre la salud infantil. | Ana Mari Costa Ramón
Universtitat Pompeu Fabra Barcelona | 2018/11/29 | Completed |
Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Estudio EPOC-ATB - R1
| Antonio Luis Aguilar Shea.
Centro de salud Puerta de Madrid. Alcalá de Henares. Comunidad de Madrid | 2017/09/28 | Completed |
Estudio multicéntrico en Atención Primaria sobre la prescripción antibiótica en otitis media y externa en adultos. | Cruz Bartolomé Moreno
Médico de familia. Centro de salud Parque Goya. Zaragoza. Servicio Aragonés de Salud. | 2017/09/28 | Completed |
Estudio de utilización de medicamentos en población pediatriática en España. | María Amparo Gil López-Oliva
Centro de Farmacovigilancia de la Comunidad de Madrid. Dirección General de Ordenación e Inspección. Consejería de Sanidad de la Comunidad de Madrid. | 2017/04/28 | Completed |
Impacto de la alerta sanitaria de la metoclopramida en la práctica clínica diaria. | Laura Urieta González
Servicio Aragonés de Salud | 2017/03/23 | Completed |
Cambios en los hábitos de prescripción de Trimetazidina en Atención Primaria tras las alertas de 2012 y 2016 de la AEMPS. | David Idoipe Rubio
Servicio Aragonés de Salud | 2017/02/23 | Completed |
Characterising the risk of major bleeding in patients with Non-Valvular Atrial Fibrillation: non-interventional study of patients taking Direct Oral Anticoagulants in the EU. | Consuelo Huerta Alvarez
AEMPS / EMA | 2017/01/26 | Completed |
Adaptación española de criterios de Beers. Repercusión en Benzodiazepinas. | Josep Pastor Cano
Servicio Murciano de Salud | 2017/01/26 | Completed |
Utilidad de la base de datos BIFAP para el estudio de seguridad y eficacia del uso de medicamentos durante el embarazo | Lucía Cea Soriano
Dpto. Medicina Preventiva y Salud Pública. Facultad de Medicina. UCM | 2017/01/26 | Completed |
Aterotrombosis y uso de medicamentos: un programa de estudios epidemiológicos de base poblacional para evaluar problemas emergentes y controversias actuales. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2016/05/26 | Completed |
Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Utilización de Benzodiazepinas y riesgo de demencia. Estudio poblacional. | Pablo Aldaz Arce
Servicio Navarro de Salud | 2016/10/27 | Completed |
Vacunación frente al virus del papiloma humano. | Elisa Martín Merino
AEMPS | 2016/06/30 | Active |
International study on trends in Clozapine utilization. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2016/06/30 | Completed |
La polimedicación en España: estudio sobre características generales y perfiles de riesgo a partir de una base de datos poblacional. | Miguel Ángel Hernández Rodríguez
Dirección del Servicio Canario de la Salud | 2016/06/30 | Completed |
Combinación de un registro de casos poblacional y una base de datos de atención primaria: una nueva aproximación para los estudios caso-población. | Francisco de Abajo Iglesias
Universidad de Alcalá de Henares | 2016/06/30 | Active |
ADVANCE – Accelerated development of vaccine benefit-risk collaboration in Europe | María Elisa Martín Merino
AEMPS | 2016/04/07 | Completed |
Title | Principal Investigator | Scientific Committee Approval | Status |
---|---|---|---|
Estudio de los factores de riesgo asociados a la neumonía adquirida en la comunidad y su tratamiento antibiótico en Atención Primaria. | Federico Martinón Torres
Hospital Clínico Universitario Santiago de Compostela | 2015/10/29 | Completed |
Elaboración estructurada de un vademécum personalizado como herramienta didáctica en la enseñanza de la terapéutica | Eduardo Puerta del Castillo
Universidad de La Laguna Servicio Canario de la Salud | 2015/07/30 | Completed |
Medicamentos como factores de protección o factores de riesgo del cáncer colorrectal. | Francisco J. de Abajo Iglesias
Universidad de Alcalá de Henares | 2015/07/30 | Completed |
Efecto del Metilfenidato en la incidencia de valvulopatías e hipertensión arterial pulmonar: un estudio de casos y controles aniadado a una cohorte. | Luis Carlos Saíz Fernández
Servicio Navarro de Salud | 2015/06/25 | Completed |
Efecto de la exposición a Ácido Valproico en la susceptibilidad a enfermedades causadas por virus con envuelta tipo Herpes. | Miguel Gil
AEMPS Francisco Sobrino Centro de Biología Molecular Severo Ochoa (UAM-CSIC) | 2015/06/25 | Completed |
Tendencia de prescripciones de benzodiacepinas en atención primaria entre 2002-2014. Factores determinantes del inicio del tratamiento, no adherencia primaria y larga duración de tratamiento. | Consuelo Huerta Alvarez
AEMPS | 2015/04/29 | Completed |
Opioid analgesics for non-cancer pain And RISK OF NONFATAL atherothrombotic events. | Francisco J. de Abajo Iglesias
Universidad de Alcalá de Henares | 2015/02/04 | Completed |
Risk of non-fatal atherothrombotic events associated with the use of calcium supplements, vitamin D, bisphosphonates and other drugs for osteoporosis. | Francisco J. de Abajo Iglesias
Universidad de Alcalá de Henares | 2015/02/04 | Completed |
Multiple Imputation Strategies for multi-database drug Safety Studies: the MISS Collaboration. Anti-osteoporosis medications and the risk of thromboembolic events: a multi-database cohort study. | Elisa Martín Merino
AEMPS | 2015/02/04 | Completed |
2022
Rodríguez-Miguel A, Fernández-Antón E, Barreira-Hernández D, et al. Statins and Colorectal Cancer Risk: A Population-Based Case-Control Study and Synthesis of the Epidemiological Evidence. J Clin Med. 2022;11(6):1528. Published 2022 Mar 10. https://doi:10.3390/jcm110615282021
2021
García Rodríguez LA, Cea Soriano L, de Abajo FJ, et al. Trends in the use of oral anticoagulants, antiplatelets and statins in four European countries: a population-based study [published online ahead of print, 2021 Nov 17]. Eur J Clin Pharmacol. 2021;10.1007/s00228-021-03250-6. https://doi:10.1007/s00228-021-03250-6
Sabaté M, Vidal X, Ballarin E, Rottenkolber M, Schmiedl S, Grave B, Huerta C, Martin-Merino E, Montero D, Leon-Muñoz LM, Gasse C, Moore N, Droz C, Lassalle R, Aakjær M, Andersen M, De Bruin ML, Souverein P, Klungel OH, Gardarsdottir H, Ibáñez L. (2021). Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008–2015). Frontiers in Pharmacology. 2021;12:2116. https://doi:10.3389/fphar.2021.682890
González-Bermejo D, Castillo-Cano B, Rodríguez-Pascual A, et al. Effect of regulatory interventions on agomelatine use in Spain: a multiple intervention time-series analysis in a nationwide electronic healthcare record database [published online ahead of print, 2021 Oct 22]. Pharmacoepidemiol Drug Saf. 2021;10.1002/pds.5374. https://doi:10.1002/pds.5374.
de Abajo FJ, Rodríguez-Martín S, Barreira D, et al. Influenza vaccine and risk of acute myocardial infarction in a population-based case-control study [published online ahead of print, 2021 Oct 13]. Heart. 2021;heartjnl-2021-319754. https://doi:10.1136/heartjnl-2021-319754.
Rodríguez-Espinosa N, González-Colaço Harmand M, Miranda Saavedra F, et al. Prescripción de inhibidores de acetilcolinesterasa y memantina en Canarias: comparación con la población española [Prescription of acetylcholinesterase inhibitors and memantine in the Canary Islands, comparison with the Spanish population.]. Rev Esp Salud Publica. 2021;95:e202109125. Published 2021 Sep 24.
de Burgos-Gonzalez, A., Bryant, V., Maciá-Martinez, M. A., & Huerta, C. (2021). A strategy for assessment and validation of major bleeding cases in a primary health care database in Spain. Pharmacoepidemiology and drug safety, 10.1002/pds.5357. Advance online publication. https://doi.org/10.1002/pds.5357
de Bont, J., Bennett, M., León-Muñoz, L. M., & Duarte-Salles, T. (2021). The prevalence and incidence rate of overweight and obesity among 2.5 million children and adolescents in Spain. Revista española de cardiología (English ed.), S1885-5857(21)00216-4. Advance online publication. https://doi.org/10.1016/j.rec.2021.07.002
Mazzucchelli, R., Rodríguez-Martín, S., García-Vadillo, A., Gil, M., Rodríguez-Miguel, A., Barreira-Hernández, D., García-Lledó, A., & de Abajo, F. J. (2021). Risk of acute myocardial infarction among new users of chondroitin sulfate: A nested case-control study. PloS one, 16(7), e0253932. https://doi.org/10.1371/journal.pone.0253932
Royé, D., Tobías, A., Figueiras, A., Gestal, S., Taracido, M., Santurtun, A., & Iñiguez, C. (2021). Temperature-related effects on respiratory medical prescriptions in Spain. Environmental research, 202, 111695. Advance online publication. https://doi.org/10.1016/j.envres.2021.111695
van den Ham, H. A., Souverein, P. C., Klungel, O. H., Platt, R. W., Ernst, P., Dell'Aniello, S., Schmiedl, S., Grave, B., Rottenkolber, M., Huerta, C., Martín Merino, E., León-Muñoz, L. M., Montero, D., Andersen, M., Aakjaer, M., De Bruin, M. L., & Gardarsdottir, H. (2021). Major bleeding in users of direct oral anticoagulants in atrial fibrillation: A pooled analysis of results from multiple population-based cohort studies. Pharmacoepidemiology and drug safety, 30(10), 1339–1352. https://doi.org/10.1002/pds.5317
Martín-Merino, E., Castillo-Cano, B., Martín-Perez, M., Llorente-García, A., & Montero-Corominas, D. (2021). Papillomavirus vaccination and Guillain-Barre Syndrome among girls: A cohort study in Spain. Vaccine, 39(31), 4306–4313. https://doi.org/10.1016/j.vaccine.2021.06.029
Sanchez Ortiz, S., Huerta, C., Llorente-García, A., Ortega, P., Astasio, P., & Cea-Soriano, L. (2021). A Validation Study on the Frequency and Natural History of Miscarriages Using the Spanish Primary Care Database BIFAP. Healthcare (Basel, Switzerland), 9(5), 596. https://doi.org/10.3390/healthcare9050596
León-Muñoz, L. M., Duarte-Salles, T., Llorente, A., Díaz, Y., Puente, D., Pottegård, A., Montero-Corominas, D., & Huerta, C. (2021). Use of hydrochlorothiazide and risk of skin cancer in a large nested case-control study in Spain. Pharmacoepidemiology and drug safety, 30(9), 1269–1278. https://doi.org/10.1002/pds.5295
Hernández-Rodríguez, M. Á., Sempere-Verdú, E., Vicens-Caldentey, C., González-Rubio, F., Miguel-García, F., Palop-Larrea, V., Orueta-Sánchez, R., Esteban-Jiménez, Ó., Sempere-Manuel, M., Arroyo-Aniés, M. P., Fernández-San José, B., de Juan-Roldán, J. I., & Ioakeim-Skoufa, I. (2021). Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data. International journal of environmental research and public health, 18(9), 4754. https://doi.org/10.3390/ijerph18094754
Sultana, J., Trotta, F., Addis, A., Brown, J. S., Gil, M., Menniti-Ippolito, F., Milozzi, F., Suissa, S., & Trifirò, G. (2020). Healthcare Database Networks for Drug Regulatory Policies: International Workshop on the Canadian, US and Spanish Experience and Future Steps for Italy. Drug safety, 43(1), 1–5. https://doi.org/10.1007/s40264-019-00871-w
Martín-Merino E, Molina-Infante J, Martín-Pérez M, Castillo-Cano B, Montero-Corominas D. Updated Incidence of Inflammatory Bowel Disease Among Girls Attended in the Spanish Public Health System. Ann Pediatr. 2021; 4(1): 1058. https://meddocsonline.org/annals-of-pediatrics/updated-incidence-of-inflammatory-bowel-disease-among-girls-attended-in-the-spanish-public.pdf
Martín-Merino, E., Castillo-Cano, B., Martín-Pérez, M., Llorente-García, A., & Montero-Corominas, D. (2021). Evaluation of the Risk of Inflammatory Bowel Disease after the HPV Vaccination in Primary Care in Spain: A Time-Varying Cohort Analysis of Around 390,000 Girls. Drug safety, 44(4), 455–466. https://doi.org/10.1007/s40264-020-01040-0
Willame, C., Dodd, C., van der Aa, L., Picelli, G., Emborg, H. D., Kahlert, J., Gini, R., Huerta, C., Martín-Merino, E., McGee, C., de Lusignan, S., Roberto, G., Villa, M., Weibel, D., Titievsky, L., & Sturkenboom, M. (2021). Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project. Drug safety, 44(3), 383–395. https://doi.org/10.1007/s40264-020-01031-1
2020
Garcia-Pérez, J.I., Serrano-Alarcón, M., Vall Castelló, J. (2020, Diciembre). Long-term unemployment subsidies and middle-age disadvantaged workers’ health. Fedea. https://fedea.net/efectos-en-salud-del-subsidio-por-desempleo-para-mayores-de-52-anos
Bollaerts, K., Ledent, E., de Smedt, T., Weibel, D., Emborg, H. D., Danieli, G., Duarte-Salles, T., Huerta-Alvarez, C., Martín-Merino, E., Picelli, G., Tramontan, L., Sturkenboom, M., & Bauchau, V. (2020). ADVANCE system testing: Benefit-risk analysis of a marketed vaccine using multi-criteria decision analysis and individual-level state transition modelling. Vaccine, 38 Suppl 2, B65–B75. https://doi.org/10.1016/j.vaccine.2019.09.034
Dodd, C., de Ridder, M., Weibel, D., Mahaux, O., Haguinet, F., de Smedt, T., de Lusignan, S., McGee, C., Duarte-Salles, T., Emborg, H. D., Huerta-Alvarez, C., Martín-Merino, E., Picelli, G., Berencsi, K., Danieli, G., & Sturkenboom, M. (2020). ADVANCE system testing: Estimating the incidence of adverse events following pertussis vaccination in healthcare databases with incomplete exposure data. Vaccine, 38 Suppl 2, B47–B55. https://doi.org/10.1016/j.vaccine.2020.03.050
Mazzucchelli, R., Rodríguez-Martín, S., García-Vadillo, A., Crespí-Villarías, N., Gil, M., Rodriguez-Miguel, A., Barreira, D., Garcia-Lledó, A., & de Abajo, F. J. (2020). Risk of acute myocardial infarction among new users of bisphosphonates: a nested case-control study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 31(12), 2403–2412. https://doi.org/10.1007/s00198-020-05538-2
Rodríguez-Martín, S., García-Lledó, A., Gil, M., Barreira-Hernández, D., Rodríguez-Miguel, A., & de Abajo, F. J. (2020). Prescription prevalence of low dose aspirin in primary prevention in the Spanish population, trends over time and associated factors. Prevalencia de prescripción del ácido acetilsalicílico a dosis bajas en prevención primaria en población española, evolución temporal y factores asociados. Medicina clínica, 155(3), 104–111. https://doi.org/10.1016/j.medcli.2019.10.012
Martín-Merino, E., Moreno-Juste, A., Castillo Cano, B., Martín Pérez, M., & Montero Corominas, D. (2021). An Estimation of the Incidence of Thyroiditis Among Girls in Primary Care in Spain. Journal of clinical research in pediatric endocrinology, 13(2), 170–179. https://doi.org/10.4274/jcrpe.galenos.2020.2020.0225
González-Bermejo, D., Rayón-Iglesias, P., Rodríguez-Pascual, A., Álvarez-Gutiérrez, A., Fernández-Dueñas, A., Montero-Corominas, D., & Huerta-Álvarez, C. (2021). Drug utilization study on immediate release Fentanyl in Spain. Prevalence, incidence, and indication. Pharmacoepidemiology and drug safety, 30(3), 371–378. https://doi.org/10.1002/pds.5118
Martín-Merino, E., Martín-Pérez, M., Castillo-Cano, B., & Montero-Corominas, D. (2020). The recording and prevalence of Inflammatory bowel disease in girls' primary care medical Spanish records. Pharmacoepidemiology and drug safety, 29(11), 1440–1449. https://doi.org/10.1002/pds.5107
Alqdwah-Fattouh, R., Rodríguez-Martín, S., de Abajo, F. J., González-Bermejo, D., Gil, M., García-Lledó, A., & Bolúmar, F. (2020). Differential effects of antidepressant subgroups on risk of acute myocardial infarction: A nested case-control study. British journal of clinical pharmacology, 86(10), 2040–2050. https://doi.org/10.1111/bcp.14299
Souverein, P. C., van den Ham, H. A., Huerta, C., Merino, E. M., Montero, D., León-Muñoz, L. M., Schmiedl, S., Heeke, A., Rottenkolber, M., Andersen, M., Aakjaer, M., De Bruin, M. L., Klungel, O. H., & Gardarsdottir, H. (2021). Comparing risk of major bleeding between users of different oral anticoagulants in patients with nonvalvular atrial fibrillation. British journal of clinical pharmacology, 87(3), 988–1000. https://doi.org/10.1111/bcp.14450
Arias Fernández, L., Pardo Seco, J., Cebey-López, M., Gil Prieto, R., Rivero-Calle, I., Martinon-Torres, F., Gil de Miguel, Á., NEUMOEXPERTOS group, Martinón-Torres, F., Vargas, D., Mascarós, E., Redondo, E., Díaz-Maroto, J. L., Linares-Rufo, M., Gil, A., Molina, J., Ocaña, D., & Rivero-Calle, I. (2019). Differences between diabetic and non-diabetic patients with community-acquired pneumonia in primary care in Spain. BMC infectious diseases, 19(1), 973. https://doi.org/10.1186/s12879-019-4534-x
Aldaz, P., Garjón, J., Beitia, G., Beltrán, I., Librero, J., Ibáñez, B., Arroyo, P., & Ariz, M. J. (2021). Association between benzodiazepine use and development of dementia. Medicina clinica, 156(3), 107–111. https://doi.org/10.1016/j.medcli.2020.02.006
de Abajo, F. J., Rodríguez-Martín, S., Lerma, V., Mejía-Abril, G., Aguilar, M., García-Luque, A., Laredo, L., Laosa, O., Centeno-Soto, G. A., Ángeles Gálvez, M., Puerro, M., González-Rojano, E., Pedraza, L., de Pablo, I., Abad-Santos, F., Rodríguez-Mañas, L., Gil, M., Tobías, A., Rodríguez-Miguel, A., Rodríguez-Puyol, D., … MED-ACE2-COVID19 study group (2020). Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study. Lancet (London, England), 395(10238), 1705–1714. https://doi.org/10.1016/S0140-6736(20)31030-8
Maciá-Martínez, M. A., Gil, M., Huerta, C., Martín-Merino, E., Álvarez, A., Bryant, V., Montero, D., & BIFAP Team (2020). Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP): A data resource for pharmacoepidemiology in Spain. Pharmacoepidemiology and drug safety, 29(10), 1236–1245. https://doi.org/10.1002/pds.5006
Braeye, T., Emborg, H. D., Llorente-García, A., Huerta, C., Martín-Merino, E., Duarte-Salles, T., Danieli, G., Tramontan, L., Weibel, D., McGee, C., Villa, M., Gini, R., Lehtinen, M., Titievsky, L., & Sturkenboom, M. (2020). Age-specific vaccination coverage estimates for influenza, human papillomavirus and measles containing vaccines from seven population-based healthcare databases from four EU countries - The ADVANCE project. Vaccine, 38(16), 3243–3254. https://doi.org/10.1016/j.vaccine.2020.02.082
Saiz, L. C., Gil, M., Alonso, A., Erviti, J., Garjón, J., & Martínez, M. (2020). Use of methylphenidate and risk for valvular heart disease: A case-control study nested in the BIFAP cohort. Pharmacoepidemiology and drug safety, 29(3), 288–295. https://doi.org/10.1002/pds.4954
Hernández-Rodríguez, M. Á., Sempere-Verdú, E., Vicens-Caldentey, C., González-Rubio, F., Miguel-García, F., Palop-Larrea, V., Orueta-Sánchez, R., Esteban-Jiménez, Ó., Sempere-Manuel, M., Arroyo-Aniés, M. P., & Fernández-San José, B. (2020). Evolution of polypharmacy in a spanish population (2005-2015): A database study. Pharmacoepidemiology and drug safety, 29(4), 433–443. https://doi.org/10.1002/pds.4956
Requena, G., Douglas, I. J., Huerta, C., & de Abajo, F. (2020). Impact of pre-exposure time bias in self-controlled case series when the event conditions the exposure: Hip/femur fracture and use of benzodiazepines as a case study. Pharmacoepidemiology and drug safety, 29(4), 388–395. https://doi.org/10.1002/pds.4959
2019
Rodríguez-Martín, S., de Abajo, F. J., Gil, M., González-Bermejo, D., Rodríguez-Miguel, A., Barreira-Hernández, D., Mazzucchelli, R., García-Lledó, A., & García-Rodríguez, L. A. (2019). Risk of Acute Myocardial Infarction Among New Users of Allopurinol According to Serum Urate Level: A Nested Case-Control Study. Journal of clinical medicine, 8(12), 2150. https://doi.org/10.3390/jcm8122150
Sanchez Ortiz, S., Llorente García, A., Astasio, P., Huerta, C., & Cea Soriano, L. (2020). An algorithm to identify pregnancies in BIFAP Primary Care database in Spain: Results from a cohort of 155 419 pregnancies. Pharmacoepidemiology and drug safety, 29(1), 57–68. https://doi.org/10.1002/pds.4910
Rodríguez-Martín, S., Martín-Merino, E., Lerma, V., Rodríguez-Miguel, A., González, O., González-Herrada, C., Ramírez, E., Bellón, T., & de Abajo, F. J. (2019). Incidence of Stevens-Johnson syndrome/toxic epidermal necrolysis among new users of different individual drugs in a European population: a case-population study. European journal of clinical pharmacology, 75(2), 237–246. https://doi.org/10.1007/s00228-018-2569-3
Martín-Merino, E., Llorente-García, A., Castillo Cano, B., Montero Corominas, D., & Huerta-Álvarez, C. (2019). The Longitudinal Incidence of Human Papillomavirus Vaccination in Spanish Primary Care in the First 10 Years After Approval. Pharmaceutical medicine, 33(6), 519–530. https://doi.org/10.1007/s40290-019-00309-9
Braeye, T., Bauchau, V., Sturkenboom, M., Emborg, H. D., García, A. L., Huerta, C., Merino, E. M., & Bollaerts, K. (2019). Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation - A contribution of the ADVANCE-project. PloS one, 14(9), e0222296. https://doi.org/10.1371/journal.pone.0222296
Emborg, H. D., Kahlert, J., Braeye, T., Bauwens, J., Bollaerts, K., Danieli, G., Duarte-Salles, T., Glismann, S., Huerta-Alvarez, C., de Lusignan, S., Martín-Merino, E., McGee, C., Correa, A., Tramontan, L., Weibel, D., & Sturkenboom, M. (2020). ADVANCE system testing: Can coverage of pertussis vaccination be estimated in European countries using electronic healthcare databases: An example. Vaccine, 38 Suppl 2, B22–B30. https://doi.org/10.1016/j.vaccine.2019.07.039
Weibel, D., Dodd, C., Mahaux, O., Haguinet, F., De Smedt, T., Duarte-Salles, T., Picelli, G., Tramontan, L., Danieli, G., Correa, A., McGee, C., Martín-Merino, E., Huerta-Alvarez, C., Berencsi, K., Emborg, H. D., Bollaerts, K., Bauchau, V., Titievsky, L., & Sturkenboom, M. (2020). ADVANCE system testing: Can safety studies be conducted using electronic healthcare data? An example using pertussis vaccination. Vaccine, 38 Suppl 2, B38–B46. https://doi.org/10.1016/j.vaccine.2019.06.040
Tin Tin Htar, M., de Ridder, M., Braeye, T., Correa, A., McGee, C., de Lusignan, S., Duarte-Salles, T., Huerta-Alvarez, C., Martín-Merino, E., Tramontan, L., Danieli, G., Picelli, G., van der Maas, N., Berencsi, K., Arnheim-Dahlström, L., Heininger, U., Emborg, H. D., Weibel, D., Bollaerts, K., & Sturkenboom, M. (2020). Advance system testing: Vaccine benefit studies using multi-country electronic health data - The example of pertussis vaccination. Vaccine, 38 Suppl 2, B31–B37. https://doi.org/10.1016/j.vaccine.2019.08.078
Gini, R., Dodd, C. N., Bollaerts, K., Bartolini, C., Roberto, G., Huerta-Alvarez, C., Martín-Merino, E., Duarte-Salles, T., Picelli, G., Tramontan, L., Danieli, G., Correa, A., McGee, C., Becker, B., Switzer, C., Gandhi-Banga, S., Bauwens, J., van der Maas, N., Spiteri, G., Sdona, E., … Sturkenboom, M. (2020). Quantifying outcome misclassification in multi-database studies: The case study of pertussis in the ADVANCE project. Vaccine, 38 Suppl 2, B56–B64. https://doi.org/10.1016/j.vaccine.2019.07.045
Rivero-Calle, I., Cebey-López, M., Pardo-Seco, J., Yuste, J., Redondo, E., Vargas, D. A., Mascarós, E., Díaz-Maroto, J. L., Linares-Rufo, M., Jimeno, I., Gil, A., Molina, J., Ocaña, D., & Martinón-Torres, F. (2019). Lifestyle and comorbid conditions as risk factors for community-acquired pneumonia in outpatient adults (NEUMO-ES-RISK project). BMJ open respiratory research, 6(1), e000359. https://doi.org/10.1136/bmjresp-2018-000359
Gil, M., González-González, R., Vázquez-Calvo, A., Álvarez-Gutiérrez, A., Martín-Acebes, M. A., Praena, B., Bello-Morales, R., Saiz, J. C., López-Guerrero, J. A., Tabarés, E., & Sobrino, F. (2019). Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP. Journal of clinical medicine, 8(9), 1442. https://doi.org/10.3390/jcm8091442
Aguilar-Shea, A. L., & Bonis, J. (2019). COPD from an everyday primary care point of view. Journal of family medicine and primary care, 8(8), 2644–2650. https://doi.org/10.4103/jfmpc.jfmpc_477_19
Martín-Merino, E., Llorente-García, A., Montero-Corominas, D., & Huerta, C. (2019). The recording of human papillomavirus (HPV) vaccination in BIFAP primary care database: A validation study. Pharmacoepidemiology and drug safety, 28(2), 201–208. https://doi.org/10.1002/pds.4674
Hedenmalm, K., Blake, K., Donegan, K., Macia, M. A., Gil, M., Williams, J., Montero, D., Candore, G., Morales, D., Kurz, X., & Arlett, P. (2019). A European multicentre drug utilisation study of the impact of regulatory measures on prescribing of codeine for pain in children. Pharmacoepidemiology and drug safety, 28(8), 1086–1096. https://doi.org/10.1002/pds.4836
Rodríguez-Miguel, A., García-Rodríguez, L. A., Gil, M., Barreira-Hernández, D., Rodríguez-Martín, S., & de Abajo, F. J. (2019). Population-based case-control study: chemoprotection of colorectal cancer with non-aspirin nonsteroidal anti-inflammatory drugs and other drugs for pain control. Alimentary pharmacology & therapeutics, 50(3), 295–305. https://doi.org/10.1111/apt.15333
Gil, M., Rodríguez-Miguel, A., Montoya-Catalá, H., González-González, R., Álvarez-Gutiérrez, A., Rodríguez-Martín, S., García-Rodríguez, L. A., & de Abajo, F. J. (2019). Validation study of colorectal cancer diagnosis in the Spanish primary care database, BIFAP. Pharmacoepidemiology and drug safety, 28(2), 209–216. https://doi.org/10.1002/pds.4686
2018
Raman, S. R., Man, K., Bahmanyar, S., Berard, A., Bilder, S., Boukhris, T., Bushnell, G., Crystal, S., Furu, K., KaoYang, Y. H., Karlstad, Ø., Kieler, H., Kubota, K., Lai, E. C., Martikainen, J. E., Maura, G., Moore, N., Montero, D., Nakamura, H., Neumann, A., … Wong, I. (2018). Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases. The lancet. Psychiatry, 5(10), 824–835. https://doi.org/10.1016/S2215-0366(18)30293-1
Rodríguez-Martín, S., Martín-Merino, E., Lerma, V., Rodríguez-Miguel, A., González, O., González-Herrada, C., Ramírez, E., Bellón, T., & de Abajo, F. J. (2018). Active surveillance of severe cutaneous adverse reactions: A case-population approach using a registry and a health care database. Pharmacoepidemiology and drug safety, 27(9), 1042–1050. https://doi.org/10.1002/pds.4622
Martín-Merino, E., Calderón-Larrañaga, A., Hawley, S., Poblador-Plou, B., Llorente-García, A., Petersen, I., & Prieto-Alhambra, D. (2018). The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study. Clinical epidemiology, 10, 643–654. https://doi.org/10.2147/CLEP.S154914
Martín-Merino, E., Petersen, I., Hawley, S., Álvarez-Gutierrez, A., Khalid, S., Llorente-Garcia, A., Delmestri, A., Javaid, M. K., Van Staa, T. P., Judge, A., Cooper, C., & Prieto-Alhambra, D. (2018). Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 29(2), 467–478. https://doi.org/10.1007/s00198-017-4308-5
2017
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